Nana is the archenemy of Alex the Lion and a major antagonist in the Madagascar franchise. She is a supporting antagonist in Madagascar, the central antagonist of A Christmas Carol and one of the main antagonists of Madagascar: Escape 2 Africa.
In the second film, she is the leader of New Yorkers because she is capable of beating up a lion with no help at all. Near the end, she is allowed to win and tricked by Alex and his father Zuba at once, by Alex giving her purse to Makunga, letting her out, and tricking him into beating him and taking him away.